Arginine and ornithine are the main precursors for citrulline synthesis in mice.

ABSTRACT: Recent isotopic tracer studies in mice, piglets, and humans have produced conflicting results as to the main carbon skeleton precursor for citrulline and arginine synthesis. This may be due in part to the different tracers infused and models used to interpret the stable isotope data. Furthermore, previous studies usually investigated a single precursor, which prevented the direct comparison among multiple precursors. To further elucidate the contribution of different precursors to citrulline synthesis, all possible enteral and plasma precursors of citrulline were studied in a mouse model during the postabsorptive and postprandial period using multitracer protocols. In addition, three different models were used to interpret the stable isotope data. The utilization of the classic precursor-p

SUBMITTER: Marini JC 

PROVIDER: S-EPMC3278269 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature