Drugs for relief of pain in patients with sciatica: systematic review and meta-analysis.

ABSTRACT:

Objective

To investigate the efficacy and tolerability of analgesic and adjuvant pain drugs typically administered in primary care for the management of patients with sciatica.

Design

Systematic review. Data source International Pharmaceutical Abstracts, PsycINFO, Medline, Embase, Cochrane Central Register of Clinical Trials (CENTRAL), CINAHL, and LILACS.

Study selection

Randomised controlled trials assessing the efficacy and tolerability of drugs versus placebo or other treatment for sciatica.

Data extraction

Two independent reviewers extracted data and assessed methodological quality using the PEDro scale. Pain and disability outcomes were converted to a common 0 to 100 scale. Data were pooled with a random effects model, and the GRADE approach was used in su

SUBMITTER: Pinto RZ 

PROVIDER: S-EPMC3278391 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature