Gene expression and genetic variation data implicate PCLO in bipolar disorder.

ABSTRACT:

Background

Genetic variation may contribute to differential gene expression in the brain of individuals with psychiatric disorders. To test this hypothesis, we identified genes that were differentially expressed in individuals with bipolar disorder, along with nearby single nucleotide polymorphisms (SNPs) that were associated with expression of the same genes. We then tested these SNPs for association with bipolar disorder in large case-control samples.

Methods

We used the Stanley Genomics Database to extract gene expression and SNP microarray data from individuals with bipolar disorder (n = 40) and unaffected controls (n = 43). We identified 367 genes that were differentially expressed in the prefrontal cortex of cases vs. controls (fold change > 1.3 and FDR q-value < .05)

SUBMITTER: Choi KH 

PROVIDER: S-EPMC3278480 | biostudies-literature | 2011 Feb

REPOSITORIES: biostudies-literature