Exposure to bisphosphonates and risk of cancer: a protocol for nested case-control studies using the QResearch primary care database.

ABSTRACT: Introduction Bisphosphonates are becoming a common treatment for osteoporosis particularly after discovery of the association between hormone replacement therapy and increased risk of breast cancer. As osteoporosis develops with age, treatment is a long-term intervention. Randomised control trials typically have limited follow-up times, which restricts investigation of the effects of the drugs on risk of primary cancers. A few observational studies have demonstrated a reduced risk of breast cancer and possibly of endometrial cancer in bisphosphonate users. Two epidemiological studies have studied the effect of the drugs on oesophageal cancer but did not reach any definite conclusions. So far, no effects on colorectal and stomach cancer have been shown. This study will investigate the assoc

SUBMITTER: Vinogradova Y 

PROVIDER: S-EPMC3278492 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature