ART: a next-generation sequencing read simulator.

ABSTRACT:

Unlabelled

ART is a set of simulation tools that generate synthetic next-generation sequencing reads. This functionality is essential for testing and benchmarking tools for next-generation sequencing data analysis including read alignment, de novo assembly and genetic variation discovery. ART generates simulated sequencing reads by emulating the sequencing process with built-in, technology-specific read error models and base quality value profiles parameterized empirically in large sequencing datasets. We currently support all three major commercial next-generation sequencing platforms: Roche's 454, Illumina's Solexa and Applied Biosystems' SOLiD. ART also allows the flexibility to use customized read error model parameters and quality profiles.

Availability

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SUBMITTER: Huang W 

PROVIDER: S-EPMC3278762 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature