Construction and analysis of the protein-protein interaction networks for schizophrenia, bipolar disorder, and major depression.

ABSTRACT:

Background

Schizophrenia, bipolar disorder, and major depression are devastating mental diseases, each with distinctive yet overlapping epidemiologic characteristics. Microarray and proteomics data have revealed genes which expressed abnormally in patients. Several single nucleotide polymorphisms (SNPs) and mutations are associated with one or more of the three diseases. Nevertheless, there are few studies on the interactions among the disease-associated genes and proteins.

Results

This study, for the first time, incorporated microarray and protein-protein interaction (PPI) databases to construct the PPI network of abnormally expressed genes in postmortem brain samples of schizophrenia, bipolar disorder, and major depression patients. The samples were collected from Brodmann

SUBMITTER: Lee SA 

PROVIDER: S-EPMC3278837 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature