Infection Strategies of Bacterial and Viral Pathogens through Pathogen-Human Protein-Protein Interactions.

ABSTRACT: Since ancient times, even in today's modern world, infectious diseases cause lots of people to die. Infectious organisms, pathogens, cause diseases by physical interactions with human proteins. A thorough analysis of these interspecies interactions is required to provide insights about infection strategies of pathogens. Here we analyzed the most comprehensive available pathogen-human protein interaction data including 23,435 interactions, targeting 5,210 human proteins. The data were obtained from the newly developed pathogen-host interaction search tool, PHISTO. This is the first comprehensive attempt to get a comparison between bacterial and viral infections. We investigated human proteins that are targeted by bacteria and viruses to provide an overview of common and special infection st

SUBMITTER: Durmus Tekir S 

PROVIDER: S-EPMC3278985 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature