Multiscale assessment of treatment efficacy in adults with ADHD: a randomized placebo-controlled, multi-centre study with extended-release methylphenidate.

ABSTRACT:

Objectives

This trial was performed to test the efficacy and safety of an extended-release formulation of methylphenidate (MPH ER).

Methods

A total of 162 adults with ADHD according to DSM-IV were treated for 8 weeks with either two daily individually body weight-adjusted doses of MPH ER up to 1 mg/kg per day (N = 84) or placebo (N = 78). The primary efficacy outcome was the Wender-Reimherr Adult Attention Deficit Disorder Scale (WRAADDS) 8 weeks after randomization. Secondary efficacy measures were the ADHD Diagnostic Checklist (ADHD-DC), the Conners Adult Attention Deficit Disorder Scale (CAARS-S:L), the Clinical Global Impression (CGI) and the Sheehan Disability Scale (SDS).

Results

At week 8 a significantly higher decline of the total WRAADDS score was found in th

SUBMITTER: Retz W 

PROVIDER: S-EPMC3279134 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature