Cord blood stem cells inhibit epidermal growth factor receptor translocation to mitochondria in glioblastoma.

ABSTRACT:

Background

Overexpression of EGFR is one of the most frequently diagnosed genetic aberrations of glioblastoma multiforme (GBM). EGFR signaling is involved in diverse cellular functions and is dependent on the type of preferred receptor complexes. EGFR translocation to mitochondria has been reported recently in different cancer types. However, mechanistic aspects of EGFR translocation to mitochondria in GBM have not been evaluated to date.

Methodology/principle findings

In the present study, we analyzed the expression of EGFR in GBM-patient derived specimens using immunohistochemistry, reverse-transcription based PCR and Western blotting techniques. In clinical samples, EGFR co-localizes with FAK in mitochondria. We evaluated this previous observation in standard glioma cell

SUBMITTER: Dasari VR 

PROVIDER: S-EPMC3279427 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature