Renal function after reduction in cadmium exposure: an 8-year follow-up of residents in cadmium-polluted areas.

ABSTRACT:

Background and objective

Long-term exposure to cadmium (Cd) causes renal dysfunction, but the change in renal function with exposure is unknown. We assessed the evolution of Cd-induced renal effects after a reduction in dietary exposure to Cd in rice.

Methods

Four hundred twelve residents in previously Cd-polluted and nonpolluted areas were examined twice, in 1998 and in 2006. Changes in blood Cd, urinary Cd, and kidney function [N-acetyl-β-d-glucosaminidase (NAG), β2-microglobulin, and albumin in urine] were measured.

Results

In the most polluted area, mean blood Cd was 8.9 μg/L and 3.3 μg/L in 1998 and in 2006, respectively, and urinary Cd was 11.6 and 9.0 μg/g creatinine. Urinary albumin in 1998 increased with urinary Cd, but no such exposure-response relation appe

SUBMITTER: Liang Y 

PROVIDER: S-EPMC3279438 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature