Occupational exposure to benzene and chromosomal structural aberrations in the sperm of Chinese men.

ABSTRACT:

Background

Benzene is an industrial chemical that causes blood disorders, including acute myeloid leukemia. We previously reported that occupational exposures near the U.S. Occupational Safety and Health Administration permissible exposure limit (8 hr) of 1 ppm was associated with sperm aneuploidy.

Objective

We investigated whether occupational exposures near 1 ppm increase the incidence of sperm carrying structural chromosomal aberrations.

Methods

We applied a sperm fluorescence in situ hybridization assay to measure frequencies of sperm carrying partial chromosomal duplications or deletions of 1cen or 1p36.3 or breaks within 1cen-1q12 among 30 benzene-exposed and 11 unexposed workers in Tianjin, China, as part of the China Benzene and Sperm Study (C-BASS). Exposed w

SUBMITTER: Marchetti F 

PROVIDER: S-EPMC3279447 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature