In utero exposure to maternal diabetes impairs vascular expression of prostacyclin receptor in rat offspring.

ABSTRACT:

Objective

To evaluate modifications of arterial structure, gene expression, and function in our model of rats exposed to maternal diabetes.

Research design and methods

Morphometric analyses of elastic vessels structure and determination of thoracic aortic gene expression profile with oligonucleotide chips (Agilent, G4130, 22k) were performed before the onset of established hypertension (3 months).

Results

Arterial parameters of in situ fixed thoracic aorta were not significantly different between control mother offspring and diabetic mother offspring (DMO). The aortic gene expression profile of DMO is characterized by modifications of several members of the arachidonic acid metabolism including a twofold underexpression of prostacyclin receptor, which could contribute

SUBMITTER: Duong Van Huyen JP 

PROVIDER: S-EPMC3279527 | biostudies-literature | 2010 Oct

REPOSITORIES: biostudies-literature