Antigen microarrays identify CNS-produced autoantibodies in RRMS.

ABSTRACT:

Objective

Multiple sclerosis (MS) is characterized by the local production of antibodies in the CNS and the presence of oligoclonal bands in the CSF. Antigen arrays allow the study of antibody reactivity against a large number of antigens using small volumes of fluid with greater sensitivity than ELISA. We investigated whether there were unique autoantibodies in the CSF of patients with MS as measured by antigen arrays and whether these antibodies differed from those in serum.

Methods

We used antigen arrays to analyze the reactivity of antibodies in matched serum and CSF samples of 20 patients with untreated relapsing-remitting MS (RRMS), 26 methylprednisolone-treated patients with RRMS, and 20 control patients with other noninflammatory neurologic conditions (ONDs) against

SUBMITTER: Quintana FJ 

PROVIDER: S-EPMC3280015 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature