Relationship between CRP polymorphism and cardiovascular events in Chinese peritoneal dialysis patients.

ABSTRACT:

Background and objectives

The single-nucleotide polymorphism (SNP) -717A→G substitution, rs2794521, was found in the promoter of the C-reactive protein (CRP) gene. Functional studies showed that A allele promoter has higher transcriptional activity than the G allele. This study investigated the association between this SNP and the outcome of Chinese patients undergoing peritoneal dialysis (PD).

Design, setting, participants, & measurements

The study included 441 new PD patients (232 men; mean age ± SD, 56.7±13.5 years). CRP genotyping was determined; patients were followed for 41.3±18.3 months for cardiovascular events.

Results

For the entire cohort, 5-year event-free survival rates did not differ between the AA and AG/GG groups (35.7% and 31.9%, respectively; P=0.64)

SUBMITTER: Poon PY 

PROVIDER: S-EPMC3280019 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature