Role of obesity, metabolic variables, and diabetes in HIV-associated neurocognitive disorder.

ABSTRACT:

Objective

To evaluate relationships between HIV-associated neurocognitive disorder and metabolic variables in a subgroup of HIV+ participants examined in a prospective, observational, multicenter cohort study.

Methods

In a cross-sectional substudy of the CNS HIV Anti-Retroviral Therapy Effects Research (CHARTER) cohort, 130 HIV+ participants provided fasting blood samples. Neurocognitive impairment (NCI) was defined by performance on neuropsychological tests adjusting for age, education, gender, and race/ethnicity. Global ratings and global deficit scores were determined. Demographics, biomarkers of HIV disease, metabolic variables, combination antiretroviral therapy (CART) history, other drug exposures, and self-reported diabetes were examined in multivariate models predict

SUBMITTER: McCutchan JA 

PROVIDER: S-EPMC3280051 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature