APOE modifies the association between Aβ load and cognition in cognitively normal older adults.

ABSTRACT:

Objective

To determine the relationship between β-amyloid (Aβ) load as measured by [(11)C]-Pittsburgh compound B (PiB) PET and cognitive function in cognitively normal older adults.

Methods

We studied 408 cognitively normal older adults who participated in the population-based Mayo Clinic Study of Aging (MCSA) from January 2009 through March 2011. The participants underwent PiB PET and neuropsychometric testing within 6 months. The association between PiB retention and cognitive function was measured by partial correlation and an interaction with APOE status was tested using linear regression after adjusting for age, sex, and education.

Results

Higher PiB retention was associated with cognitive performance (Spearman partial r = -0.18; p < 0.01), specifically the memor

SUBMITTER: Kantarci K 

PROVIDER: S-EPMC3280056 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature