Assessing the joint effect of population stratification and sample selection in studies of gene-gene (environment) interactions.

ABSTRACT:

Background

It is well known that the presence of population stratification (PS) may cause the usual test in case-control studies to produce spurious gene-disease associations. However, the impact of the PS and sample selection (SS) is less known. In this paper, we provide a systematic study of the joint effect of PS and SS under a more general risk model containing genetic and environmental factors. We provide simulation results to show the magnitude of the bias and its impact on type I error rate of the usual chi-square test under a wide range of PS level and selection bias.

Results

The biases to the estimation of main and interaction effect are quantified and then their bounds derived. The estimated bounds can be used to compute conservative p-values for the association te

SUBMITTER: Cheng KF 

PROVIDER: S-EPMC3280159 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature