Identifying neighborhoods of coordinated gene expression and metabolite profiles.

ABSTRACT: In this paper we investigate how metabolic network structure affects any coordination between transcript and metabolite profiles. To achieve this goal we conduct two complementary analyses focused on the metabolic response to stress. First, we investigate the general size of any relationship between metabolic network gene expression and metabolite profiles. We find that strongly correlated transcript-metabolite profiles are sustained over surprisingly long network distances away from any target metabolite. Secondly, we employ a novel pathway mining method to investigate the structure of this transcript-metabolite relationship. The objective of this method is to identify a minimum set of metabolites which are the target of significantly correlated gene expression pathways. The results revea

SUBMITTER: Hancock T 

PROVIDER: S-EPMC3280297 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature