Identification of potential apicoplast associated therapeutic targets in human and animal pathogen Toxoplasma gondii ME49.

ABSTRACT:

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Toxoplasma gondii ME49 is an obligatory intracellular apicomplexa parasite that causes toxoplasmosis in humans, domesticated and wild animals. Waterborne outbreaks of acute toxoplasmosis worldwide reinforce the transmission of Toxoplasma gondii ME49 to humans through contaminated water and may have a greater epidemiological impact than previously believed. In the quest for drug and vaccine target identification subtractive genomics involving subtraction between the host and pathogen genome has been implemented for enlisting essential pathogen specific proteins. Using this approach, our analysis on both human and Toxoplasma gondii ME49 reveals that out of 7987 protein coding sequences of the pathogen, 950 represent essential non human-homologous proteins. Subcellular loca

SUBMITTER: Saremy S 

PROVIDER: S-EPMC3280436 | biostudies-literature | 2011

REPOSITORIES: biostudies-literature