Ontology highlight
ABSTRACT:
SUBMITTER: Stadhouders R
PROVIDER: S-EPMC3280550 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
The EMBO journal 20111213 4
The key haematopoietic regulator Myb is essential for coordinating proliferation and differentiation. ChIP-Sequencing and Chromosome Conformation Capture (3C)-Sequencing were used to characterize the structural and protein-binding dynamics of the Myb locus during erythroid differentiation. In proliferating cells expressing Myb, enhancers within the Myb-Hbs1l intergenic region were shown to form an active chromatin hub (ACH) containing the Myb promoter and first intron. This first intron was foun ...[more]