Adaptive models for gene networks.
Ontology highlight
ABSTRACT:
SUBMITTER: Shin YJ
PROVIDER: S-EPMC3280989 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Publications
Adaptive models for gene networks.
Shin Yong-Jun YJ Sayed Ali H AH Shen Xiling X
PloS one 20120216 2
Biological systems are often treated as time-invariant by computational models that use fixed parameter values. In this study, we demonstrate that the behavior of the p53-MDM2 gene network in individual cells can be tracked using adaptive filtering algorithms and the resulting time-variant models can approximate experimental measurements more accurately than time-invariant models. Adaptive models with time-variant parameters can help reduce modeling complexity and can more realistically represen ...[more]
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