Introgression of ivermectin resistance genes into a susceptible Haemonchus contortus strain by multiple backcrossing.

ABSTRACT: Anthelmintic drug resistance in livestock parasites is already widespread and in recent years there has been an increasing level of anthelmintic drug selection pressure applied to parasitic nematode populations in humans leading to concerns regarding the emergence of resistance. However, most parasitic nematodes, particularly those of humans, are difficult experimental subjects making mechanistic studies of drug resistance extremely difficult. The small ruminant parasitic nematode Haemonchus contortus is a more amenable model system to study many aspects of parasite biology and investigate the basic mechanisms and genetics of anthelmintic drug resistance. Here we report the successful introgression of ivermectin resistance genes from two independent ivermectin resistant strains, MHco4(WRS)

SUBMITTER: Redman E 

PROVIDER: S-EPMC3280990 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature