Plasmacytoid dendritic cells sequester high prion titres at early stages of prion infection.

ABSTRACT: In most transmissible spongiform encephalopathies prions accumulate in the lymphoreticular system (LRS) long before they are detectable in the central nervous system. While a considerable body of evidence showed that B lymphocytes and follicular dendritic cells play a major role in prion colonization of lymphoid organs, the contribution of various other cell types, including antigen-presenting cells, to the accumulation and the spread of prions in the LRS are not well understood. A comprehensive study to compare prion titers of candidate cell types has not been performed to date, mainly due to limitations in the scope of animal bioassays where prohibitively large numbers of mice would be required to obtain sufficiently accurate data. By taking advantage of quantitative in vitro prion deter

SUBMITTER: Castro-Seoane R 

PROVIDER: S-EPMC3280992 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature