Reciprocal metabolic perturbations in the adipose tissue and liver of GPIHBP1-deficient mice.

ABSTRACT:

Objective

Gpihbp1-deficient (Gpihbp1-/-) mice lack the ability to transport lipoprotein lipase to the capillary lumen, resulting in mislocalization of lipoprotein lipase within tissues, defective lipolysis of triglyceride-rich lipoproteins, and chylomicronemia. We asked whether GPIHBP1 deficiency and mislocalization of catalytically active lipoprotein lipase would alter the composition of triglycerides in adipose tissue or perturb the expression of lipid biosynthetic genes. We also asked whether perturbations in adipose tissue composition and gene expression, if they occur, would be accompanied by reciprocal metabolic changes in the liver.

Methods and results

The chylomicronemia in Gpihbp1-/- mice was associated with reduced levels of essential fatty acids in adipose tissue

SUBMITTER: Weinstein MM 

PROVIDER: S-EPMC3281771 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature