Sample reproducibility of genetic association using different multimarker TDTs in genome-wide association studies: characterization and a new approach.

ABSTRACT: Multimarker Transmission/Disequilibrium Tests (TDTs) are very robust association tests to population admixture and structure which may be used to identify susceptibility loci in genome-wide association studies. Multimarker TDTs using several markers may increase power by capturing high-degree associations. However, there is also a risk of spurious associations and power reduction due to the increase in degrees of freedom. In this study we show that associations found by tests built on simple null hypotheses are highly reproducible in a second independent data set regardless the number of markers. As a test exhibiting this feature to its maximum, we introduce the multimarker 2-Groups TDT (mTDT(2G)), a test which under the hypothesis of no linkage, asymptotically follows a χ2 distribution wi

SUBMITTER: Abad-Grau MM 

PROVIDER: S-EPMC3281822 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature