Selective serotonin reuptake inhibitor use is associated with right ventricular structure and function: the MESA-right ventricle study.

ABSTRACT:

Purpose

Serotonin and the serotonin transporter have been implicated in the development of pulmonary hypertension (PH). Selective serotonin reuptake inhibitors (SSRIs) may have a role in PH treatment, but the effects of SSRI use on right ventricular (RV) structure and function are unknown. We hypothesized that SSRI use would be associated with RV morphology in a large cohort without cardiovascular disease (N = 4114).

Methods

SSRI use was determined by medication inventory during the Multi-Ethnic Study of Atherosclerosis baseline examination. RV measures were assessed via cardiac magnetic resonance imaging. The cross-sectional relationship between SSRI use and each RV measure was assessed using multivariable linear regression; analyses for RV mass and end-diastolic volume (RV

SUBMITTER: Ventetuolo CE 

PROVIDER: S-EPMC3281845 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature