The Correlation of Il28B Genotype With Sustained Virologic Response In Romanian patients With Chronic Hepatitis C.

ABSTRACT:

Background

Multiple variables influencing the sustained virologic response (SVR) in chronic hepatitis C have been evaluated. One of them is genetic polymorphism near the IL28B gene.

Objectives

The aim of this study was to evaluate the influence of IL28B genotypes on SVR rates in a group of patients with chronic hepatitis C from the western part of Romania.

Patients and methods

A retrospective study was performed in 107 consecutive patients, previously treated with standard-of-care medication for chronic hepatitis C, identified from the databases of 2 centers. Patient demographics, viral load before treatment and at 12, 24, and 72 weeks from the treatment start, and IL28B genotype were evaluated.

Results

Among the 107 patents in the study group, 54 patients had

SUBMITTER: Sporea I 

PROVIDER: S-EPMC3282030 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature