Identification of a chrXq27.3 microRNA cluster associated with early relapse in advanced stage ovarian cancer patients.

ABSTRACT: A major challenge in advanced-stage epithelial ovarian cancer (EOC) is prediction of chemoresistant relapse. Our aim was to identify a microRNA (miRNA) signature associated with early relapse in advanced-stage EOC patients. miRNA expression was assessed by microarray profiling in training (n = 55) and test (n = 30) sets selected on the basis of time to relapse (TTR), followed by internal quantitative reverse transcriptase-PCR validation on a set of 45 consecutive cases unselected for clinical response and external in silico validation on publicly available datasets. Thirty-two differentially expressed miRNAs in early vs. late relapsing patients were identified in the training set. In the test set, 8 of these, belonging to a cluster located on chrXq27.3, were down-modulated in early relapsi

SUBMITTER: Bagnoli M 

PROVIDER: S-EPMC3282083 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature