Anti-inflammatory activity of an ethanolic Caesalpinia sappan extract in human chondrocytes and macrophages.

ABSTRACT:

Ethnopharmacological relevance

Caesalpinia sappan is a common remedy in Traditional Chinese Medicine and possesses diverse biological activities including anti-inflammatory properties. Osteoarthritis (OA) is a degenerative joint disease with an inflammatory component that drives the degradation of cartilage extracellular matrix. In order to provide a scientific basis for the applicability of Caesalpinia sappan in arthritic diseases, the present study aimed to assess the effects of an ethanolic Caesalpinia sappan extract (CSE) on human chondrocytes and macrophages.

Materials and methods

Primary human chondrocytes were isolated from cartilage specimens of OA patients. Primary cells, SW1353 chondrocytes and THP-1 macrophages were serum-starved and pretreated with different conc

SUBMITTER: Wu SQ 

PROVIDER: S-EPMC3282169 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature