Gout and the risk for incident heart failure and systolic dysfunction.

ABSTRACT:

Objective

To test the hypothesis that gouty arthritis (gout) is a risk factor for incidence of heart failure and for echocardiographic measures signifying subclinical heart failure.

Design

Post-hoc, longitudinal and cross-sectional analyses of a prospective cohort study where data were collected in 4-year intervals since 1971.

Settings

The population-based Framingham Offspring Study.

Participants

4989 adults (mean age 36 years, 52% women) free of clinical heart failure at baseline.

Outcome measures

Incident heart failure, echocardiographic measures of left ventricular systolic dysfunction, dilatation and hypertrophy.

Results

Participants with gout (n=228) had two to three times higher incidence of clinical heart failure and echocardiographic measu

SUBMITTER: Krishnan E 

PROVIDER: S-EPMC3282286 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature