A common variant of the MACC1 gene is significantly associated with overall survival in colorectal cancer patients.

ABSTRACT:

Background

The newly discovered metastasis-associated in colon cancer-1 (MACC1) gene is a key regulator of the HGF/MET pathway. Deregulation of HGF/MET signaling is reported as a prognostic marker for tumorigenesis, early stage invasion, and metastasis. High expression levels of MACC1 have been associated with colon cancer metastasis and reduced survival. Potential links between the genetic diversity of the MACC1 locus and overall survival are unknown. We therefore investigated the association between MACC1 tagging single nucleotide polymorphisms (SNPs) and overall survival in a large cohort of colorectal cancer patients.

Methods

The study included 318 subjects with histopathologically proven colorectal cancer at the Academic Teaching Hospital Feldkirch, Austria. Survival da

SUBMITTER: Lang AH 

PROVIDER: S-EPMC3282635 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature