Altered networks in bothersome tinnitus: a functional connectivity study.

ABSTRACT:

Background

The objective was to examine functional connectivity linked to the auditory system in patients with bothersome tinnitus. Activity was low frequency (< 0.1 Hz), spontaneous blood oxygenation level-dependent (BOLD) responses at rest. The question was whether the experience of chronic bothersome tinnitus induced changes in synaptic efficacy between co-activated components. Functional connectivity for seed regions in auditory, visual, attention, and control networks was computed across all 2 mm(3) brain volumes in 17 patients with moderate-severe bothersome tinnitus (Tinnitus Handicap Index: average 53.5 ± 3.6 (range 38-76)) and 17 age-matched controls.

Results

In bothersome tinnitus, negative correlations reciprocally characterized functional connectivity between aud

SUBMITTER: Burton H 

PROVIDER: S-EPMC3282646 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature