Encephalitis temporally associated with live attenuated Japanese encephalitis vaccine: four case reports.

ABSTRACT:

Background

Japanese encephalitis (JE) vaccination is the most effective measure for preventing JE disease. The live attenuated JE vaccine, which has shown good efficacy and safety, has been widely used in China.

Case presentations

We report four laboratory-confirmed JE cases detected in JE-endemic areas during the JE virus (JEV) transmission season, who all received a first dose of live attenuated JE vaccine within 2 weeks prior to the onset of illness. All cases presented with acute encephalitis and rapidly reduced consciousness. All cerebrospinal fluid (CSF) samples from the patients were positive for JEV-specific immunoglobulin M (IgM) antibodies, but viral isolation and polymerase chain reaction (PCR) detection of JEV were both negative.

Conclusions

It is difficul

SUBMITTER: Jia N 

PROVIDER: S-EPMC3282669 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature