Deletion and down-regulation of HRH4 gene in gastric carcinomas: a potential correlation with tumor progression.

ABSTRACT:

Background

Histamine is an established growth factor for gastrointestinal malignancies. The effect of histamine is largely determined locally by the histamine receptor expression pattern. Histamine receptor H4 (HRH4), the newest member of the histamine receptor family, is positively expressed on the epithelium of the gastrointestinal tract, and its function remains to be elucidated. Previously, we reported the decreased expression of HRH4 in colorectal cancers and revealed its correlation with tumor proliferation. In the current study, we aimed to investigate the abnormalities of HRH4 gene in gastric carcinomas (GCs).

Methodology/principal findings

We analyzed H4R expression in collected GC samples by quantitative PCR, Western blot analysis, and immunostaining. Our results s

SUBMITTER: Zhang C 

PROVIDER: S-EPMC3282702 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature