Mechanisms underlying stage-1 TRPL channel translocation in Drosophila photoreceptors.

ABSTRACT:

Background

TRP channels function as key mediators of sensory transduction and other cellular signaling pathways. In Drosophila, TRP and TRPL are the light-activated channels in photoreceptors. While TRP is statically localized in the signaling compartment of the cell (the rhabdomere), TRPL localization is regulated by light. TRPL channels translocate out of the rhabdomere in two distinct stages, returning to the rhabdomere with dark-incubation. Translocation of TRPL channels regulates their availability, and thereby the gain of the signal. Little, however, is known about the mechanisms underlying this trafficking of TRPL channels.

Methodology/principal findings

We first examine the involvement of de novo protein synthesis in TRPL translocation. We feed flies cycloheximide, v

SUBMITTER: Lieu MH 

PROVIDER: S-EPMC3282777 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature