IPLA2β overexpression in smooth muscle exacerbates angiotensin II-induced hypertension and vascular remodeling.

ABSTRACT:

Objectives

Calcium independent group VIA phospholipase A(2) (iPLA(2)β) is up-regulated in vascular smooth muscle cells in some diseases, but whether the up-regulated iPLA(2)β affects vascular morphology and blood pressure is unknown. The current study addresses this question by evaluating the basal- and angiotensin II infusion-induced vascular remodeling and hypertension in smooth muscle specific iPLA(2)β transgenic (iPLA(2)β-Tg) mice.

Method and results

Blood pressure was monitored by radiotelemetry and vascular remodeling was assessed by morphologic analysis. We found that the angiotensin II-induced increase in diastolic pressure was significantly higher in iPLA(2)β-Tg than iPLA(2)β-Wt mice, whereas, the basal blood pressure was not significantly different. The media thick

SUBMITTER: Calderon LE 

PROVIDER: S-EPMC3282780 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature