Identification and analysis of the RNA degrading complexes and machinery of Giardia lamblia using an in silico approach.

ABSTRACT:

Background

RNA degradation is critical to the survival of all cells. With increasing evidence for pervasive transcription in cells, RNA degradation has gained recognition as a means of regulating gene expression. Yet, RNA degradation machinery has been studied extensively in only a few eukaryotic organisms, including Saccharomyces cerevisiae and humans. Giardia lamblia is a parasitic protist with unusual genomic traits: it is binucleated and tetraploid, has a very compact genome, displays a theme of genomic minimalism with cellular machinery commonly comprised of a reduced number of protein components, and has a remarkably large population of long, stable, noncoding, antisense RNAs.

Results

Here we use in silico approaches to investigate the major RNA degradation machinery i

SUBMITTER: Williams CW 

PROVIDER: S-EPMC3282835 | biostudies-literature | 2011 Nov

REPOSITORIES: biostudies-literature