Chromatin-driven de novo discovery of DNA binding motifs in the human malaria parasite.

ABSTRACT:

Background

Despite extensive efforts to discover transcription factors and their binding sites in the human malaria parasite Plasmodium falciparum, only a few transcription factor binding motifs have been experimentally validated to date. As a consequence, gene regulation in P. falciparum is still poorly understood. There is now evidence that the chromatin architecture plays an important role in transcriptional control in malaria.

Results

We propose a methodology for discovering cis-regulatory elements that uses for the first time exclusively dynamic chromatin remodeling data. Our method employs nucleosome positioning data collected at seven time points during the erythrocytic cycle of P. falciparum to discover putative DNA binding motifs and their transcription factor bindi

SUBMITTER: Harris EY 

PROVIDER: S-EPMC3282892 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature