Screening of chemicals for human bioaccumulative potential with a physiologically based toxicokinetic model.

ABSTRACT: Human bioaccumulative potential is an important element in the risk assessment of chemicals. Due to the high number of synthetic chemicals, there exists the need to develop prioritisation strategies. The purpose of this study was to develop a predictive tool for human bioaccumulation risk assessment that incorporates not only the chemical properties of the compounds, but also the processes that tend to decrease the concentration of the compound such as metabolisation. We used a generic physiologically based toxicokinetic model that based on in vitro human liver metabolism data, minimal renal excretion and a constant exposure was able to assess the bioaccumulative potential of a chemical. The approach has been analysed using literature data on well-known bioaccumulative compounds and liver

SUBMITTER: Tonnelier A 

PROVIDER: S-EPMC3282909 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature