Identification of putative retinoic acid target genes downstream of mesenchymal Tbx1 during inner ear development.

ABSTRACT:

Background

The T-box transcription factor Tbx1 is expressed in the otic vesicle and surrounding mesoderm of the periotic mesenchyme (POM) during inner ear development. Mesenchymal Tbx1 is essential for inner ear development, with conditional mutants displaying defects in both the auditory and vestibular systems. We have previously reported that mesodermal Tbx1 loss of function mutants (Mest-KO) have reduced expression of retinoic acid (RA) metabolic genes, Cyp26a1 and Cyp26c1, in the POM, consistent with other studies showing an increase in mesodermal RA reporter expression in Tbx1-/- embryos. However, putative RA effector genes whose expression is altered downstream of increased otic mesenchymal-epithelial RA signaling have remained elusive.

Results

Here we report the ident

SUBMITTER: Monks DC 

PROVIDER: S-EPMC3282991 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature