The rise and fall of breakpoint reuse depending on genome resolution.

ABSTRACT:

Background

During evolution, large-scale genome rearrangements of chromosomes shuffle the order of homologous genome sequences ("synteny blocks") across species. Some years ago, a controversy erupted in genome rearrangement studies over whether rearrangements recur, causing breakpoints to be reused.

Methods

We investigate this controversial issue using the synteny block's for human-mouse-rat reported by Bourque et al. and a series of synteny blocks we generated using Mauve at resolutions ranging from coarse to very fine-scale. We conducted analyses to test how resolution affects the traditional measure of the breakpoint reuse rate.

Results

We found that the inversion-based breakpoint reuse rate is low at fine-scale synteny block resolution and that it rises and eventu

SUBMITTER: Attie O 

PROVIDER: S-EPMC3283316 | biostudies-literature | 2011 Oct

REPOSITORIES: biostudies-literature