Hepatitis B surface gene 145 mutant as a minor population in hepatitis B virus carriers.

ABSTRACT:

Background

Hepatitis B virus (HBV) can have mutations that include the a determinant, which causes breakthrough infection. In particular, a single mutation at amino acid 145 of the surface protein (G145) is frequently reported in the failure of prophylactic treatment. The aim of this study was to evaluate the frequency of the a determinant mutants, especially the G145 variant, in Japan, where universal vaccination has not been adopted.

Methods

The present study was a retrospective study. The study cohorts were defined as follows: group 1, children with failure to prevent mother-to-child transmission despite immunoprophylaxis (n = 18, male/female = 8/10, age 1-14 years; median 6 years); group 2, HBV carriers who had not received vaccination or hepatitis B immunoglobulin (n =

SUBMITTER: Komatsu H 

PROVIDER: S-EPMC3283482 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature