Estrogen metabolism and risk of breast cancer in postmenopausal women.

ABSTRACT:

Background

Estrogens are recognized causal factors in breast cancer. Interindividual variation in estrogen metabolism may also influence the risk of breast cancer and could provide clues to mechanisms of breast carcinogenesis. Long-standing hypotheses about how estrogen metabolism might influence breast cancer have not been adequately evaluated in epidemiological studies because of the lack of accurate, reproducible, and high-throughput assays for estrogen metabolites.

Methods

We conducted a prospective case-control study nested within the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO). Participants included 277 women who developed invasive breast cancer (case subjects) and 423 matched control subjects; at PLCO baseline, all subjects were aged 55-74 ye

SUBMITTER: Fuhrman BJ 

PROVIDER: S-EPMC3283536 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature