A putative P-type ATPase required for virulence and resistance to haem toxicity in Listeria monocytogenes.

ABSTRACT: Regulation of iron homeostasis in many pathogens is principally mediated by the ferric uptake regulator, Fur. Since acquisition of iron from the host is essential for the intracellular pathogen Listeria monocytogenes, we predicted the existence of Fur-regulated systems that support infection. We examined the contribution of nine Fur-regulated loci to the pathogenicity of L. monocytogenes in a murine model of infection. While mutating the majority of the genes failed to affect virulence, three mutants exhibited a significantly compromised virulence potential. Most striking was the role of the membrane protein we designate FrvA (Fur regulated virulence factor A; encoded by frvA [lmo0641]), which is absolutely required for the systemic phase of infection in mice and also for virulence in an a

SUBMITTER: McLaughlin HP 

PROVIDER: S-EPMC3283593 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature