Monocyte gene expression signature of patients with early onset coronary artery disease.

ABSTRACT: The burden of cardiovascular disease (CVD) cannot be fully addressed by therapy targeting known pathophysiological pathways. Even with stringent control of all risk factors CVD events are only diminished by half. A number of additional pathways probably play a role in the development of CVD and might serve as novel therapeutic targets. Genome wide expression studies represent a powerful tool to identify such novel pathways. We compared the expression profiles in monocytes from twenty two young male patients with premature familial CAD with those from controls matched for age, sex and smoking status, without a family history of CVD. Since all patients were on statins and aspirin treatment, potentially affecting the expression of genes in monocytes, twelve controls were subsequently treated

SUBMITTER: Sivapalaratnam S 

PROVIDER: S-EPMC3283726 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature