Involvement of cyclin K posttranscriptional regulation in the formation of Artemia diapause cysts.

ABSTRACT:

Background

Artemia eggs tend to develop ovoviviparously to yield nauplius larvae in good rearing conditions; while under adverse situations, they tend to develop oviparously and encysted diapause embryos are formed instead. However, the intrinsic mechanisms regulating this process are not well understood.

Principal finding

This study has characterized the function of cyclin K, a regulatory subunit of the positive transcription elongation factor b (P-TEFb) in the two different developmental pathways of Artemia. In the diapause-destined embryo, Western blots showed that the cyclin K protein was down-regulated as the embryo entered dormancy and reverted to relatively high levels of expression once development resumed, consistent with the fluctuations in phosphorylation of posit

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC3283732 | biostudies-literature | 2012

REPOSITORIES: biostudies-literature