Association between IL17A/IL17RA Gene Polymorphisms and Susceptibility to Alopecia Areata in the Korean Population.

ABSTRACT:

Background

Alopecia areata is marked by autoimmune assault on the hair follicle resulting in hair loss. T helper 17 cell subset has important roles in protecting the host against extracellular pathogens, however, also promotes inflammatory pathology in autoimmune disease, and it expresses both interleukin (IL)-17A and IL-17F, which can signal via the IL-17 receptor A.

Objective

To investigate the significance of IL17A and IL17RA gene polymorphisms in the susceptibility to alopecia areata.

Methods

We conducted case-control association study of 238 alopecia areata patients and 270 matched healthy controls. Allele frequency of total 2 single nucleotide polymorphims in the IL17A gene and 4 single nucleotide polymorphims in the IL17RA gene were studied. The statistical ana

SUBMITTER: Lew BL 

PROVIDER: S-EPMC3283852 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature