CoREST acts as a positive regulator of Notch signaling in the follicle cells of Drosophila melanogaster.

ABSTRACT: The Notch signaling pathway plays important roles in a variety of developmental events. The context-dependent activities of positive and negative modulators dramatically increase the diversity of cellular responses to Notch signaling. In a screen for mutations affecting the Drosophila melanogaster follicular epithelium, we isolated a mutation in CoREST that disrupts the Notch-dependent mitotic-to-endocycle switch of follicle cells at stage 6 of oogenesis. We show that Drosophila CoREST positively regulates Notch signaling, acting downstream of the proteolytic cleavage of Notch but upstream of Hindsight activity; the Hindsight gene is a Notch target that coordinates responses in the follicle cells. We show that CoREST genetically interacts with components of the Notch repressor complex, Hai

SUBMITTER: Domanitskaya E 

PROVIDER: S-EPMC3283875 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature