Genetic correlates influencing immunopathogenesis of HIV infection.

ABSTRACT: Variability to HIV infection, its progression as well as responsiveness to antiretroviral therapy (ART) is observed among individuals including viraemia controllers or exposed uninfected, rapid versus slow progressors and ART responders compared to non responders. This differential responsiveness/vulnerability to HIV-1 is governed by multiple host genetic factors that include HLA, cytokines, chemokines, their receptors and others. This review highlights the influence of these genetic factors on HIV/AIDS outcome; however, in India, the information in this area is very limited and most of these genetic studies have been conducted in Caucasian and South African populations. Considering the population-specific differences in the frequencies of protective or susceptibility favouring alleles and

SUBMITTER: Sharma G 

PROVIDER: S-EPMC3284087 | biostudies-literature | 2011 Dec

REPOSITORIES: biostudies-literature