Angiopoietin-2 levels are associated with retinopathy and predict mortality in Malawian children with cerebral malaria: a retrospective case-control study*.

ABSTRACT:

Objective

To investigate the relationship among the angiopoietin-Tie-2 system, retinopathy, and mortality in children with cerebral malaria.

Design

A case-control study of retinopathy-positive vs. retinopathy-negative children with clinically defined cerebral malaria.

Setting

Queen Elizabeth Central Hospital in Blantyre, Malawi.

Subjects

One hundred fifty-five children presenting with severe malaria and meeting a strict definition of clinical cerebral malaria (Blantyre Coma Score ≤ 2, Plasmodium falciparum parasitemia, no other identifiable cause for coma) were included in the study.

Interventions

None.

Measurements and main results

Clinical and laboratory parameters were recorded at admission and funduscopic examinations were performed. Admission

SUBMITTER: Conroy AL 

PROVIDER: S-EPMC3284252 | biostudies-literature | 2012 Mar

REPOSITORIES: biostudies-literature